This policy brief summarizes the key activities and learnings of the BSR Stars S3 - Smart Specialisation through Cross-sectoral Bio-, Circular- andDigital Ecosystems project 2016-2019. The project focused on how to engage business and research actors in the implementation of smart specialisation. This information is essential for public and private sector actors looking for new ways to improve regional innovation capacity and form inter-regional value chains within shared focus areas in the Baltic Sea Region.