Delivery by caesarean section and childhood cancer: a nationwide follow-up study in three countries.
2014 (English)In: BJOG : an international journal of obstetrics and gynaecology, ISSN 1470-0328Article in journal (Refereed) Published
To investigate the association between delivery by caesarean section and risk of childhood cancer.
A population-based, follow-up study using register data from three countries.
Denmark, Sweden and Finland.
Children born in Denmark (1973-2007), Sweden (1973-2006) and Finland (randomly selected sample of 90%, 1987-2007; n = 7 029 843).
Exposure was delivery by caesarean section and the outcome was childhood cancer diagnosis. Follow-up started from birth and ended at the first of the following dates: cancer diagnosis, death, emigration, day before 15th birthday or end of follow-up. Cox regression was used to obtain hazard ratios.
MAIN OUTCOME MEASURES:
Childhood cancer diagnosis.
A total of 882 907 (12.6%) children were delivered by caesarean section. Of these, 30.3% were elective (n = 267 603), 35.9% unplanned (n = 316 536) and 33.8% had no information on planning (n = 298 768). Altogether, 11 181 children received a cancer diagnosis. No evidence of an increased risk of childhood cancer was found for children born by caesarean section (hazard ratio, 1.05; 95% confidence interval, 0.99, 1.11). No association was found for any major type of childhood cancer, or when split by the type of caesarean section (elective/unplanned).
The evidence does not suggest that caesarean section is a risk factor for the overall risk of childhood cancer and possibly not for subtypes of childhood cancer either
Place, publisher, year, edition, pages
Caesarean Section, Childhood Cancer, Follow-Up Studies, Mode of Delivery, Risk
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:norden:org:diva-2568DOI: 10.1111/1471-0528.12667PubMedID: 24521532OAI: oai:DiVA.org:norden-2568DiVA: diva2:705154