Lithuania has one of the highest suicide rates for men in the world (81.7 per 100,000 men). 21.7% of the population feels depressed. A salutogenic model of health developed by Antonovsky provides new knowledge for betterunderstanding of the behaviour of individuals and explains why some individuals fall ill under stress and why some do not. The study is focussed on the analysis of sense of coherence (SOC) on the population sample of Lithuania (n=3390) using a simplified way of measuring SOC developed by Lundberg and Nyström Peck at the Swedish Institute for Social Research of Stockholm University. The data of the study showed that people with low SOC (60.1%) predominate among the Lithuanian population. A strong correlation between low SOC, depression and stress was found. Additional studies, preferably longitudinal, are needed to identify possible relationshipsbetween cognitive processes (SOC) and biological mechanisms, causing adverse effects on mental health