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  • 1.
    Lesén, Eva
    et al.
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Carlsten, Anders
    Department of Research and Development, The National Corporation of Swedish Pharmacies (Apoteket AB), Gothenburg, Sweden.
    There is a trend in the utilization of psychotropics among elderly towards recommended drugs.2010In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 19, no 10, p. 1095-9Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To analyse trends in sales of potentially inappropriate psychotropic substances (PIPS) in relation to drugs recommended by Drug and Therapeutics Committees (DTC drugs) among 75-year olds and among individuals born 1925 in Sweden.

    METHODS: Trends in sales of PIPS and DTC drugs among 75-year olds and among individuals born 1925 in Sweden during 2000-2008 were analysed with linear regression models. Sales were measured as defined daily doses per 1000 inhabitants and day. PIPS were defined according to a proposal from the Swedish National Board of Health and Welfare. The selection of DTC drugs was based on a review of recommendations from local DTCs.

    RESULTS: Among 75-year olds, PIPS sales decreased 38% and DTC drugs sales increased 31% from 2000 to 2008. The hypnotic PIPS decreased 45%, while the DTC hypnotics increased 36%. The total sales of PIPS to individuals born in 1925 decreased 12% from 2000 to 2008. The DTC drugs increased 115%. Sales of hypnotic PIPS decreased 12%, and the hypnotic DTC drugs increased 120%.

    CONCLUSIONS: The findings indicate a trend towards the utilization of DTC drugs rather than PIPS.

  • 2.
    Silwer, Louise
    et al.
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Petzold, Max
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Hallas, Jesper
    Ståhlsby Lundborg, Cecilia
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Statins and nonsteroidal anti-inflammatory drugs-an analysis of prescription symmetry.2006In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 15, no 7, p. 510-1Article in journal (Refereed)
  • 3.
    Silwer, Louise
    et al.
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Ståhlsby Lundborg, Cecilia
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Patterns of drug use during a 15 year period: data from a Swedish county, 1988--2002.2005In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 14, no 11, p. 813-20Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To present and interpret drug prescription patterns, related to various groups of the population in a Swedish county, in order to estimate the prevalence of drug use in different age groups.

    METHODS: Data on prescriptions, dispensed March-May 1988-2002, were combined with population statistics of Halland, a county in the south of Sweden, and analysed. Number of defined daily doses (DDD) per 100 inhabitants and day and prescriptions per 100 inhabitants and 3 months were used as indicators of drug prevalence.

    RESULTS: The total drug exposure in the population of Halland nearly doubled during the 15-year period. The most frequently used drugs overall, in 2002, were psycholeptics (N05), analgesics (N02), antibacterials (J01) and sex hormones (G03). Nearly 30% of the women of 15-69 years were exposed to sex hormones. Multiplied drug prevalence among people above 60 was found for antithrombotic drugs (B01), agents acting on the renin-angiotensin system (C09), sex hormones (G03), serum lipid reducing agents (C10), antidepressants (N06) and drugs for peptic ulcer and GORD (A02B).

    CONCLUSIONS: The increase in drug prescribing over the 15 years concerned both symptom-related treatments, like hormone replacement therapy, analgesics, antidepressants and drugs for acid-related disorders, as well as preventive treatments, like antithrombotics, lipid-lowering drugs and antihypertensives. The unit DDD/100 inhabitants and day gives a fairly correct measure of the percentage treated for chronic disorders. However, for short-term treatment courses and especially for drug use in children, number of prescriptions/100 inhabitants and adequate period of time, is easier to interpret.

  • 4.
    Silwer, Louise
    et al.
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Stålsby Lundborg, Cecilia
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Petzold, Max
    Nordic Council of Ministers, Nordic School of Public Health NHV.
    Prevalence of purchase of antihypertensive and serum lipid-reducing drugs in Sweden--individual data from national registers.2008In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 17, no 1, p. 37-42Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To determine the prevalence of purchase of prescribed antihypertensive and/or serum lipid-reducing pharmaceutical preparations among different age groups, from the age of 45, in the Swedish population. Further, to calculate the percentage of the population, from the age of 60, who purchased these pharmaceuticals without having had a circulatory diagnosis in the Hospital Discharge Register the last 7 years, or having purchased nitrate vasodilators, as an attempt to estimate the proportion of primary preventive treatments.

    METHODS: A cross-sectional study, of individual data on prescriptions for antihypertensives (C02-C03, C07-C09) and serum lipid-reducing agents (C10), dispensed from July to December 2005 for the Swedish population. Data were obtained from the new Swedish Prescribed Drugs Register. The data were related to population statistics, and linked to data on diagnoses of cardiovascular disease (I00-I99), from the Swedish Hospital Discharge Register 1998-2004. Data on individuals with purchase of antihypertensive or serum lipid-reducing agents, but without a diagnosis of cardiovascular disease, were also linked to purchase of nitrate vasodilators (C01D).

    RESULTS: Among Swedes of 60 years and above, 53% purchased antihypertensive or serum lipid-reducing pharmaceuticals, and 30% purchased the pharmaceuticals without having been hospitalized for a coronary or cerebrovascular event during the previous 7 years, or having purchased prescribed nitrate vasodilators during 6 months.

    CONCLUSION: Over half of the Swedish senior population purchased prescribed antihypertensive or serum lipid-reducing drugs during 6 months in 2005. The magnitude of the prevalence points to the importance of intensified follow-up of both adverse effects and of effectiveness of these drugs.

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