A joint workshop on Alignment and overall strategy for the handling of in silico methods in human health assessment of plant protection products in the Northern Zone was organised in 2024. To avoid animal testing, computer models (in silico models) are sometimes used to predict the toxicity of unknown chemicals based on data from similar chemicals. Together with other non-animal approaches, in silico methods are a part of next generation risk assessment. However, assessing pitfalls and weighing the applicability and quality of in silico predictions may be challenging for regulatory use. The focus of the workshop was on the newly published OECD (Q)SAR framework (QAF) and its applicability in a regulatory setting. The new framework facilitates the assessment of in silico methods for regulatory risk assessors and makes in silico data more accessible.