This report provides a review of studies that have been performed to date using non-target screening (NTS) and suspect screening (SS) to identify substances in articles, chemical products, and recycled materials. Comprehensive data on the occurrence and hazard properties of chemicals in different products and articles represent a cornerstone of a sound chemicals management system. In the absence of reliable supply-chain information novel analytical methods involving NTS and SS could facilitate identification and prioritization of (groups of) chemicals for regulatory risk management measures under e.g. the REACH and CLP regulations. In summary, NTS and SS display a high potential for identifying regulatory-relevant substances although standardized workflows, enhanced quality assurance measures, and collaborative trials to improve comparability and reliability of findings.